Cardiac Toxicity: Issue for Drug Safety; Goal for Prediction
نویسندگان
چکیده
blockbuster COX-2 inhibitor Vioxx (rofecoxib) as a result of an increased risk of heart attack in Vioxx users underscores the prominent role that cardiac toxicity continues to play in ensuring drug safety within the pharmaceutical industry. While the precise mechanism of Vioxx-induced cardiotoxicity is unclear, cardiac liabilities have surfaced recently for a surprising number of approved drugs that have been subsequently withdrawn.
منابع مشابه
O-3: Drug Repositioning by Merging Gene Expression Data Analysis and Cheminformatics Target Prediction Approaches
The transcriptional responses of drug treatments combined with a protein target prediction algorithm was utilised to associate compounds to biological genomic space. This enabled us to predict efficacy of compounds in cMap and LINCS against 181 databases of diseases extracted from GEO. 18/30 of top drugs predicted for leukemia (e.g. Leflunomide and Etoposide) and breast cancer (e.g. Tamoxifen a...
متن کاملIn Silico Prediction of Chemical Toxicity for Drug Design Using Machine Learning Methods and Structural Alerts
During drug development, safety is always the most important issue, including a variety of toxicities and adverse drug effects, which should be evaluated in preclinical and clinical trial phases. This review article at first simply introduced the computational methods used in prediction of chemical toxicity for drug design, including machine learning methods and structural alerts. Machine learn...
متن کاملAn advection-diffusion multi-layer porous model for stent drug delivery in coronary arteries
Arterial drug concentration distribution determines local toxicity. The safety issues dealt with Drug-Eluting Stents (DESs) reveal the needs for investigation about the effective factors contributing to fluctuations in arterial drug uptake. The current study focused on the importance of hypertension as an important and controversial risk factor among researchers on the efficacy of Heparin-Eluti...
متن کاملIn silico prediction of drug safety: despite progress there is abundant room for improvement.
Predictive models for drug safety are crucial for helping to avoid costly late-stage failures. We review recent work on models for genotoxicity, liver toxicity, CYP450 inhibition and cardiotoxicity. These models have improved somewhat in recent years, and research has expanded into new frontiers, such as the prediction of liver toxicity. However, much more needs to be done.:
متن کاملA new classifier-based strategy for in-silico ion-channel cardiac drug safety assessment
There is currently a strong interest in using high-throughput in-vitro ion-channel screening data to make predictions regarding the cardiac toxicity potential of a new compound in both animal and human studies. A recent FDA think tank encourages the use of biophysical mathematical models of cardiac myocytes for this prediction task. However, it remains unclear whether this approach is the most ...
متن کامل